The self-sufficiency rate of soybean production in our country was low.By exploring the effects of balanced application of nitrogen，phosphorus，and potassium in soybeans，as well as the application of humic acid water-soluble fertilizer nutrient regulation technology at different growth stages of soybeans，on soybean production and soil chemical properties，technical support could be provided for improving soybean yield，quality，and sustainable soil utilization.Six treatments were set up，including:T1:Conventional fertilization (15-15-15) 450 kg/hm²+humic acid water-soluble fertilizer 3.75 L/hm² (sprayed once during the initial flowering stage)；T2:Conventional fertilization (15-15-15) 450 kg/hm²+humic acidwater-soluble fertilizer 3.75 L/hm² (sprayed once during the initial flowering and pod setting stages)；T3:Formula fertilizer (12-18-15) 450 kg/hm²+humic acid water-soluble fertilizer 3.75 L/hm² (sprayed once during the initial flowering stage)；T4:Formula fertilizer (12-18-15) 450 kg/hm²+humic acid water-soluble fertilizer 3.75 L/hm² (sprayed once during the initial flowering and podding stages)；T5:Conventional fertilization (15-15-15) 450 kg/hm²+urea 150 kg/hm² (applied once during the initial flowering stage)；CK:Blank control (no basal fertilizer+spraying an equal amount of water once during the initial flowering period).The nutrient absorption，growth status，dependence rate of soybean yield on soil，and changes in soil chemical properties of different treatments of soybeans were systematically analyzed.The results showed that soybean yield exhibited the order of T4>T2>T3>T1>T5>CK，with each treatment showing an increase of 11.88%-25.73%，compared to CK；The nitrogen content in soybean seeds increased，ranked as T4>T2>T3>T1>T5>CK.The phosphorus and potassium contents in seeds showed an increase in T1>T5.The crude protein content of T4 soybean increased by 1.22%，0.83%，1.34%，4.84%，and 5.72%，compared to T1，T2，T3，T5，and CK，respectively.During the experiment，there was no change in soil pH and nutrient levels of various indicators in the fertilization treatment.Compared with the CK treatment，T1，T2，T3，T4，and T5 treatments all increases soil nutrient content.Among them，T4 had the largest increase in organic matter，available phosphorus，and available potassium content，with an increase of 12.36%，15.03%，and 15.60%，respectively，compared with CK.The dependence rate of soybean yield on soil showed as T4